Electrical properties of a molecular ion channel
نویسندگان
چکیده
منابع مشابه
Tuning the electrical properties of the heart by differential trafficking of KATP ion channel complexes
The copy number of membrane proteins at the cell surface is tightly regulated. Many ion channels and receptors present retrieval motifs to COPI vesicle coats and are retained in the early secretory pathway. In some cases, the interaction with COPI is prevented by binding to 14-3-3 proteins. However, the functional significance of this antagonism between COPI and 14-3-3 in terminally differentia...
متن کاملMolecular evolution of voltage-sensitive ion channel genes: on the origins of electrical excitability.
We have analyzed nucleic acid and amino acid sequence alignments of a variety of voltage-sensitive ion channels, using several methods for phylogenetic tree reconstruction. Ancient duplications within this family gave rise to three distantly related groups, one consisting of the Na+ and Ca++ channels, another the K+ channels, and a third including the cyclic nucleotide-binding channels. A serie...
متن کاملMolecular determinants of permeation in a fluoride-specific ion channel
Fluoride ion channels of the Fluc family combat toxicity arising from accumulation of environmental F-. Although crystal structures are known, the densely packed pore region has precluded delineation of the ion pathway. Here we chart out the Fluc pore and characterize its chemical requirements for transport. A ladder of H-bond donating residues creates a 'polar track' demarking the ion-conducti...
متن کاملMolecular dynamics simulation of a synthetic ion channel.
A molecular dynamics simulation has been performed on a synthetic membrane-spanning ion channel, consisting of four alpha-helical peptides, each of which is composed of the amino acids leucine (L) and serine (S), with the sequence Ac-(LSLLLSL)3-CONH2. This four-helix bundle has been shown experimentally to act as a proton-conducting channel in a membrane environment. In the present simulation, ...
متن کاملStructural. Electrical and Catalytic Properties of Ion-Implanted Oxides
The potential application of ion implantation to modify the surfaces of ceramic materials is discussed. Changes in the chemical composition and microstructure result in important variations of the electrical and catalytic properties of oxides. PACS: 66.30, 81.40, 81.60, 61.70 Since the introduction of ion implantation as a surface modification technique, the electrical [1, 2], optical [3], magn...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Recueil des Travaux Chimiques des Pays-Bas
سال: 2010
ISSN: 0165-0513
DOI: 10.1002/recl.19841030903